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Boston ma elevation elevator panel. Elevated alkaline phosphatase in the absence of cholestasis. Condition key diagnostic clue alcohol astalt without cirrhosisggt drugsherbstoxins introduction within 3 mo. I know this is a long message but i really am anxious to know if anyone has any clue as to what might be wrong.
Alkaline phosphatase is a membrane bound enzyme present in many tissues. Elevated wbc can also indicate presence of infection or cancer. Alp and ggt elevations can indicate a problem with bile flow through the liver.
63 indicated liver disease as their primary diagnosis despite normal ggt levels18. A number of pitfalls can be encountered in the interpretation of common blood liver function tests. Initial screening tests for liver disease include a cbc biochemistry panel and urinalysis.
Igm anti hav igm anti. Elevated alt ggt alp and b12. When i went to school a lot of junior high kids got hep a just.
Consider these abnormalities in the context of the clinical setting to arrive at a diagnosis. These tests can be normal in patients with chronic hepatitis or cirrhosis. Combination of any two liver enzyme andor function.
Three major isoenzymes contribute to total serum alp. Marked elevation is typical of cholestasis often with elevated ggt or bone disorders usually normal ggt. Its concentrated in the liver kidneys gut and bones.
The gamma glutamyl transferase ggt test may be used to determine the cause of elevated alkaline phosphatase alpboth alp and ggt are elevated in disease of the bile ducts and in some liver diseases but only alp will be elevated in bone diseasetherefore if the ggt level is normal in a person with a high alp the cause of the elevated alp is most likely bone disease. Alkaline phosphatase is high if the blood levels surpass 130 ul. Alkaline phosphatase alp alp comes mainly from the cells lining bile ducts but is also in bone.
Alkaline phosphatase and ggt increased. It was found that 56 failed to mention muscle damage as a potential diagnosis despite the markedly elevated ck level of the patient. High levels may point to problems with these organs.
Blood test results showed elevated aspartate ast alt and ck but normal ggt. Isoenzyme analysis may help identify source. High alkaline phosphatase levels generally indicate cholestatic or infiltrative disease whereas elevated aspertate aminotransferase and alanine aminotransferase levels most likely stem from hepatocellular injury.
If the ggt concentration is normal a high alp result suggests bone disease. Bone liver and corticosteroid isoenzymes138 bone alp accounts for about one third of the total serum alp and is elevated with conditions associated with increased osteoblastic activity such as bone growth. Alkaline phosphatase is an enzyme that helps you digest food and maintain strong bones.
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